Clodronate Liposome And The Importance Of Its Discovery

By Roxanne Cruz


Before, thousands of residents die because certain medicine or vaccination was not yet available in the market. However, due to the discoveries of these geniuses, curing the once deadly diseases are now possible. Since medical science plays a very fascinating role in medicine science, clodronate liposome was discovered, accidentally. Because of the great role it plays in curing and treating diseases, it will surely be of great importance to medical science.

Clodronic acid or clodronic sodium, or more commonly known as clodronate liposome is the first generation of non nitrogen bisphosphonate. It is a drug and approved scientifically to treat and prevent the cases of osteoporosis. This happened when women already reach the stage of post menopausal time. In experimental science, it is used to decrease macrophages.

These are white blood cells within tissues. Macrophages are produced by the division of the white blood cells formed in the bone marrow and spleen. These kind of white blood cell is known to be as monocytes which ingest foreign particles after it was formed. Basically, macrophage is the core of the system which fight against infectious viruses and diseases.

Liposomes, in cell biology, are the microscopic sac that are composed of fatty liquids. They are used in the experimental research of the cell. It can be supplied with drugs used in curing cancer and other diseases. It usually contained of liquid solutions and composed of phospholipids.

Science discovered clodronate liposome acts for the suppression of the macrophage. Indeed immune system defends the invasion of infectious viruses and bacteria. Through immune response, it will attack the invaders that will cause diseases to the organ or body. However, the immune system can be the source of disease in the body.

In natural circumstances, the healthy immune system will cope diseases up like coughs and colds. In the contrary, the damaged system will attack every cells it will eat each particles, both the healthy and damaged. When this doom happens, severe illnesses will take place affecting the body from functioning well.

The system protects the body from foreign invasion, as mentioned earlier. However, it will also create damages resulted by transplant rejection. This rejection happens when a a newly transplanted organ was placed in the body. As this happens, the system will attack the cells forcefully leading to rejection. One of the effects of the rejection is the autoimmune disorder or the identification of healthy cells wrongly and trying to fight off them because they thought that they are foreign.

Because of the autoimmune disorders that could actually happen, here comes the discovery of the mighty liposome. This is composed of bisphosphonate and will deplete macrophages. After it was transported, macrophage will detect that it is alien. In result, it will engulf it through the thing so called phagocytosis.

This discovery marked a significance in the history of medicine industry. Not only that the cancers will be treated, other diseases will be as well. However, even though clodronate liposome is reported to help treat cancer and many other illnesses, consult your own doctor first. This is to ensure your health will not be at risk. Ask prescriptions from your doctor if you could have one.




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